[Page 1]
For Mr Irwin

You reason very justly concerning the colour of his skin
which is certainly owing not to bile but to effuse serum.
Perhaps this effusion is the cause of the itchiness as
I have known it upon other occasions; but this leads

---

[Page 2]

me to no new remedy: for I can see no means of pre¬
venting the effusion but by either strengthening the
tone of the system which we have been attempting by Chaly¬
beates or by drawing off the serum more than plentifully by
urine & for this last purpose I can find nothing his
condition can admit of, more proper than the Solution
formerly advised & he may return to it again & if
it does not purge him it will not at all interfere
with the Chalybeate. You may by giving the Solution
[par reprises?] ¹ try to prevent its doing more than keep
the belly regular, which will at the same time direct
it more certainly to the kidnies.

In the meantime the diminution of the swelling of
his legs is favourable, & gives me hopes that the effusion
of serum elsewhere will also be diminished. As the
Chalybeate sits so well on his Stomach I think the
dose of it maybe increased as far as can be without
increasing the quantity of water he takes it in.

I am still of the same opinion with respect to Lauda¬
num & his Diet.