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The Inclosed Case was delivered to me late on the 23d
& I begun to answer it yesterday but was prevented from finishing

I am disposed to speak candidly in every case but I cannot
↑possibly↑ be insensible to the anxiety of the patient & her friend in the
present case as not to deliver my opinion very freely & honestly.
But as I cannot at present give my opinion very positively. The manner
of acquiring the Disease was a little singular & the Symptons have
hitherto been as much so & was it not for the pains of the Shins I could
find very little certainly of any thing venereal in the case. However
I determined nothing but this that if there is any thing venereal in the
case I have no doubt of removing it & obviating all its
consequences & at any rate I shall think it adviseable to take the
measures that may render the patient service in this respect,
but I will not determine what these measures shall be till I have
an answer to the Queries set down below & in the meantime
I have inclosed a prescription which on every supposition
I think proper & it will keep everything in a safe way till I can
write again.

The P{illeg} Prescription is for Pills of which at first one
is to be taken every night & morning. The sometimes occasions
a little sickness at stomach or a little giddiness of the head with a
slight trembling. If the first doses have any of these effects the
dose must not be increased but if the first doses have no sensible
effects for next day the dose may ↑be two pills & in the same manner the dose may↑ be increased by a single Pill every
day till some sensible effect is absorbed. When anything of that
kind is observed the dose is to be no farther increased till the
effects

The Queries I want to have answered are the following.

"Did the infected Person with the infected part touch
the very part of our own Patient on which the swelling two days
afterwards came?

Did that part on which the swelling came suffer
any particular hurt or bruise?

Did ever any part about the lips on their outside or inside
come to [fret?], lose the skin or shew any ulceration.

Did ever any swelling or kernal appear in one or other lisk
or groin.?

How much Mercurial Ointment was rubbed upon the
outside or inside of the thighs at one time or in a day?

Did ever this anointment taint the breath or affect the
mouth, to what degree did that happen & how long was that
continued?

Was it during the time of this anointing & in proportion as
that proceeded that the tumor on the outside came to diminish
& go away.

Whether did the Ointment applied to the thighs seem to
occasion feverish fits & so manifestly that the feverish fits were
increased as the ointment was continued?

During the anointing were the bowels ever threatned with any
purging.

During the aointing did the patient sweat much?

Is the pain of the legs confined to the middle of the Shins or does
it shoot along the legs {illeg} are sometimes severe in the knees or
ankles? Are they in any place ever so severe {illeg} in the
night as to prevent Sleep?

What or do any nervous complaints continue to distress
out patient? Does she grow stronger since she laid aside
medecines?

When these Queries are answered I shall be ready to give
my final advice. Tho I apprehend no danger I am heartily concerned
for the [anxiety?] that persons in this situation must have and
I shall always grudge no pains relieve it as much as I can.