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I am favoured with yours of the 20th
and I am happy to find in the first place, that you yourself
are in good health. -- The Case you communicated is clearly
and distinctly narrated; but the nature of it is not easily
ascertained especially now that the ailment is so much
fixed in the Pudenda. There can be no doubt of their
being a peculiar acrimony in her humours; and one proof
of it is, that you formerly did her so much service by the
*Alterative Mercurial Course and the other measures that
you pursued along with it. I am not however certain
that the same Course would not prevent all returns of
the Affection of the Pudenda and at least I would not
advise it till you try another remedy in which I have
much confidence and which will give less trouble to the
Patient. This is the Mezereon which probably you are
well acquainted with; but as I do not find it very

generally known or very properly employed, I shall give
you some remarks on the best manner of using it

It is only the Bark of the Root, that is of any use
The woody part of the Root is of none at all & therefore
you must take only the smallest fibres or the bark peeled
off from the larger Woody parts. When it is fresh it is
exceedingly acrid to the Taste; but will keep tolerably well
for a long time in a dry State, but if you get any that have
been kept for some time, take care that it is such, as still
retains all its Acrimony. Of this choice bark you may
at first employ a Dram to make a bottle of Decoction
but if this gives no uneasy heat in the Stomach, you
may increase the quantity to two drams; and if the Bark
is in good condition it is seldom, that the Stomach will
bear a larger proportion than that of two Drams to
two pounds of Decoction.- I generally employ at the
same time two Ounces of good Sarsaparilla; and to

this I put four pounds of Water, and boil till one pound
is consumed & then add the Mezereon continuing the boiling
till another pound is boiled away; and then strain off
the Decoction. This may be made more agreeable to the
Palate either by Liquorice or raisins added in the
ordinary way.- Of this Decoction I order a Bottle to be
taken in divided draughts in the Course of twenty four hours.
and when any considerably Acrimony is to be washed
out of the blood, I advise it to be continued every day, for
a Month. In this way, I have found a very effectual
remedy in many obstinate Cases; and I hope it will
succeed with you. If however it should not, please let me
know, and I shall advise further as well as I can.

During the Course of it, I would have the Issue in the Arm
and the Cold bathing continued; and the Lotion with the
simple Aqua Calcis is very proper. I think the Bark
with [Aq. Cal. mag. compt.?] may both be delayed till the

Course of Mezereon is over. You have said nothing to
me of this patients Diet. If any trials have been made
in this respect, I leave you to be directed by your experience
but if there is nothing already decided, I will give you my
opinion, that a Diet entirely of Milk and Farinacea with
very little animal food; and without any wine at all
is likely to be of service. If during the Course of Mezereon
any Costiveness should come on it will be proper to remove
it, by such a saline Cathartic as you formerly employed
tho I would not give it in Doses to purge much.

To conclude; the Case is singular and I beg to know
the result of it. Please present my respectful Compli¬
ments to Mr Busfield and your Son. Wishing
heartily your own good health I am with great
regard