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I was favoured with yours of
the 21st. Curt. yesterday- Since the report of Mr. Bethunes
Case on the 20th. the Symptomes have been pritty
much the same as mentiond that day, in that
report which was wrote from Kilconqr. it was men¬
tion'd that Mr. Bethune had that morning of his
own accord taken the Electuary which operated
very freely 7 or 8 times in the Evening I found Him
a good deal fatigued, and had but a poor night
disturbed with breathlessness, and some degree of Cough
Tuesday Morning, still rather flaggd which continued
thro' the day, Urine still in small quantity no
Drought, dryness in the mouth better, Swelling of
the Limbs and Thighs the same, Appetite not so
bad- some degree of hoarsness and Cough and did not
sleep well thro' the night from frequent returns
of difficult Breathing which he now observes to
come on immediately when put in a horizontal

Takes above two hours exercise ↑in↑ the Carriage
daily-

I have constantly urged Mr. Bethune to continue
regularly and to increase the Squills & Nitre
as his Stomach will bear them- and that the
griping effect of the Squills which sometimes
they do, I have this day prevaild upon him to
take the Laudanam to obviate that-

As the Disease evidently so gaining ground
Mr. Bethune is now resolv'd Soon to set off
for Edinr.- till that time shall persist with
the present plan- as the ¹ [however?] is not yet
fix'd upon shall be glad to hear from you
in Course- With very much Respect

Doctor Cullen
Professor of Medicine
University Edinr.