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Your favour of the 4th. Octr. last was,
by the detention of the vessells from Leith, delayed from coming to
my hands for a very long time, & only arrived so, that the advice and
prescriptions could reach but reach Miss Sanderson eight or ten days
before her death. –– The musk was tryed, but she being then exceedingly
weak, a small quantity only was given, so that it could not be said what
its effects might have been.

Although her menses were regular & in sufficient quantity when I
had the honour to write you, they were soon afterwards suppressed, chiefly
owing, at that time, to the violent shock her frame sufferd on the death of
her mother; which happened soom after I wrote. From that time all her
complaints were aggravated, and the short Cough I mentioned in the re¬
presentation of her Case became more continued & deeper seated. –– Its progress
was from this time very rapid, & there soon followed a copious purulent
Expectoration, which quickly reduced the little remaining strength she had

Although when I wrote you, I hoped, the short tickling Cough she had,
might be symptomatic, yet I feard her Lungs might be soon affected
from knowing the predisposition many of that family had to Pulmonary
Affections: And my fears was but too well founded ––––

I cannot help expressing the high degree of satisfaction your
very kind letter afforded me –– The office of superintending the health
of my fellow Creatures is a charge of the most weighty importance, as
often, on the prudent or imprudent management of their Cases, depend
the life or death of the Patients. Many a sleepless night & anxious
day has my situation, in that respect, given me; more especially as there
is no person here of superior skill to advise with, or be directed by, so
that the approbation of my Conduct by so able a Judge gives me the
most heartfelt pleasure I am capable of receiving. ––––

My wife & I have long entertained the highest degree of gratitude
for your friendly conduct towards me; But alas, can show it ↑in↑ no way
but, by words, assuring you, that the most lively remembrance of it shall
ever be keeped up in our hearts.

She has made a pair of Shetland worsted Gloves for you which we can
not be restrained from offering for your acceptance, & if you like them,
let us know, & you shall be supplyed with them from time to time as
you need them –– Acept them dear Sir as a very triffling testimony
of the sincere regard your friendly conduct towards me has indelibly
fixed on my heart. I am

Doctor William Cullen
Professor of the Practice of Physic
in the University of
Edinr.